Antibody Recruiting Molecules (ARMs)
Antibody Recruiting Molecules (ARMs) are bifunctional molecules composed of two active heads attached with a linker in-between. One head, which we call the Antibody Binding Terminus (ABT), attaches to antibodies. The other head, which we call the Target Binding Terminus (TBT) attaches to the disease cells targeted for destruction. These molecules can be engineered with different TBTs giving the platform tremendous flexibility to act on a variety of indications.
How ARMs Work
The ARM's TBT binds tightly with specific antigens expressed on the disease cell's surface. The ABT attaches to antibodies already present in the patient's body and the micro-environment of the disease cells. Antibodies coat the disease cell activating an immune response that leads to the destruction of the cell.
Similar to biologics, ARMs leverage the patient's own immunity in the fight against disease and utilizes mechanism of actions found universally in all patients. Unlike biologics, as small molecules, ARMs have the added benefit of being inherently non-immunogenic, having greater biological reach, and being relatively easy to store, produce, and deliver (non-intravenous modes of delivery).