We're hiring!

Kleo Pharmaceuticals is an emerging company at the forefront of synthetic organic chemistry and immunology. We are passionate about developing new, innovative small molecule immunotherapies to treat patients with cancer as well as other life-threatening diseases. Our Headquarters is located adjacent to Yale University in the vibrant city of New Haven, CT.

Please email us your resume to hr@kleopharmaceuticals.com with the position title in the subject line if you are interested. We look forward to meeting you.

Please scroll down to the following positions:

  • Group Leader/Director, Cancer Immunology

  • Associate/Research Scientist, Immuno-Oncology

  • Associate/Research Scientist, Biochemistry


Group Leader/Director, Cancer Immunology

Description of the Role

We are seeking a highly motivated scientist and team player to lead our Cancer Immunology group and make major scientific contributions to advance our product pipeline. This individual will lead research team efforts and develop the strategies, technologies, and procedures to achieve important milestones in program development.

This position will incorporate a mixture of management and laboratory benchwork responsibilities. Accordingly, our ideal candidate will have proficiency in a wide range of laboratory techniques–especially assays using human and/or mouse immune cells, flow cytometry, ELISA, mammalian cell culture. Experience with antibodies and in vivo tumor models is highly desirable. Experience with cutting-edge techniques and technologies in your field is a plus. Immuno-oncology drug development experiment is essential.

Our ideal candidate may be working in either an industrial or an academic environment, but will possess a strong scientific research background and managerial experience. If you are passionate about advancing healthcare and this position is in agreement with your career goals, we would love to hear from you. A relocation package is available for qualified applicants and based upon level of work experience.

Candidate Qualifications

  • PhD in Immunology, Cell Biology, Cancer Research, or related field

  • 5+ years of additional post-graduate and/or pharmaceutical experience in immunology, oncology and/or cell biology is required

  • Demonstrated record of scientific achievement and innovation (i.e. strong publication record or drug development portfolio)

  • Robust research experience in immunology assay development using multiple approaches (ie ADCC/CDC assays, FACS, ELISA, other) is essential

  • Immuno-oncology assay development experience, in vivo tumor models, and as well as a desire to continue in a laboratory-focused role

  • Proficiency in molecular biology techniques including cloning, transfection, PCR, qPCR is required

  • Capacity to thrive in a competitive, multi-disciplinary environmen


Associate/research scientist, immuno-oncology

Description of the Role

We are seeking a highly skilled and motivated Scientist to join the Immuno-Oncology team at Kleo Pharmaceuticals to make major contributions to advance our product pipeline.

The successful candidate will support pre-clinical development of immune cell engaging bispecific small molecules. The candidate will be responsible for the development and execution of in vitro assays to characterize compounds using flow cytometry, ELISA, and live cell imaging. The candidate will also be responsible for validating novel targets in Kleo’s pipeline. Ideal candidates will possess an understanding of immunology principles, and extensive laboratory experience in cellular biology/immunology with a focus on in vitro assay implementation and development.  The candidate must be independent, able to interpret the results of experiments, highly organized with attention to detail, and pocess an abiltiy to clearly and effectively communicate and collaborate with colleagues on the team.

Principal Responsibilities:

  • ·       Planning and execution of cell based in vitro assays

    ·       Validation of novel immunotherapeutic targets

    ·       Perform multi-parameter flow cytometry (FACS) and analysis

    ·       Perform various immunoassay techniques (e.g., ELISAs and cell purification)

    ·       Cell culture, including passage and expansion of tumor cells for tumor cell implantation

    ·       Compound reconstitution for administration of therapeutics and in vitro testing

    ·       Support of ongoing in vivo efficacy studies

    ·       Clearly communicate results to management and colleagues

 Candidate Qualifications:

  • B.S. with 8+, M.S. with 6+, or PhD with 2+ years of experience working in the immunology and/or immuno-oncology fields in an academic or industry setting

  • Ability to multitask and manage multiple projects simultaneously

  • Candidate should be a strong team player with excellent oral and written communication skills and a demonstrated ability to work independently to design experiments, interpret data, and troubleshoot. Ability to multitask and manage multiple projects simultaneously.

  • Candidate should be competent in standard scientific software used for data analysis (e.g., Microsoft Excel and Prism), as well as Microsoft Word and Powerpoint.


Description of the Role

We are seeking a highly motivated scientist and team player to join our Biochemistry group and make major scientific contributions to advance our product pipeline. This individual will assist in early stage discovery projects in immuno-oncology and develop the technologies and protocols to achieve important milestones in program development.

This position will require experience with the production, purification, and pre-clinical development of biologics, including monoclonal antibodies and/or their derivatives. Expertise with antibody drug conjugation (ADC) and their analysis. This candidate will possess a current knowledge in developing Antibody conjugation methods, product purification, and analysis of drug-to-antibody ratio (DAR).

Accordingly, our ideal candidate will have proficiency in a wide range of laboratory techniques–especially pertaining to the characterization of bi-specific antibodies, antibody-derived fragments (Fab, scFv, etc), and/or monoclonal antibodies. Experience with cutting-edge technologies in ADC field is a plus.

This position requires at least 2 years of relevant industry or academic experience, ideally with preparation of ADC and analytical methods development, and strong scientific research background. Our hire will work as part of a multidisciplinary team in a fast-paced environment. If you are passionate about advancing healthcare and this position is in agreement with your career goals, we would love to hear from you.

Candidate Qualifications 

  • B.S. with 8+, M.S. with 6+, or PhD with 2+ years of experience working with ADC in pharmaceutical or academic lab

  • Hands on experience with various methods of ADC preparation, purification and analysis

  • Expertise with binding assays (i.e. ELISA, MST, FRET, AlphaScreen, flow cytometry, etc.) using recombinant and cellular surface proteins is a plus

  • The ideal candidate would have strong knowledge about ADC, biochemistry of antibody derivatives (i.e. BITE, DART, TandAb, Fab, scFv, etc.) and immuno-oncology targets

  • Ability to work as part of a multidisciplinary team and multitask between different projects.

  • Experience with standard data analysis software (e.g. Microsoft Excel, Prism, etc.)

associate/research scientist, biochemistry